yEvo突变浏览器:通过交互式数据可视化增强学生对实验进化和基因组学的理解
Leah Anderson1, Jasmine Schoch1,2, Eleftheria Anastasia2
1Department of Genome Sciences, University of Washington; Seattle, WA 98195, USA.
bioRxiv : the preprint server for biology
|August 8, 2025
概括
在课堂上使用酵母 (yEvo) 的实验进化有助于学生研究遗传适应. 一个新的网络工具,yEvo Mutation Browser,简化了对酵母基因组测序数据的分析,以更好地理解进化.
科学领域:
- 遗传学和进化生物学
- 生物信息学和计算生物学
- 科学教育科学教育教育.
背景情况:
- 实验进化允许在受控的选择性压力下研究基因型-表型关系.
- yEvo计划在高中课堂上使用面包酵母 (Saccharomyces cerevisiae) 教导分子遗传学和进化.
- 从进化酵母中分析全基因组测序数据对学生在识别显著突变方面提出了挑战.
研究的目的:
- 开发一个直观的网络工具,yEvo Mutation Browser,用于可视化和语境化基因组测序数据.
- 帮助学生和研究人员解释由实验进化导致的遗传变化.
- 为比较实验进化数据集与现有的yEvo数据提供一个平台.
主要方法:
- yEvo 突变浏览器是使用 R Shiny 开发的.
- 该工具具有交互式染色体地图,突变类型分类图表和基因查看器.
- 它允许用户上传并将自己的数据集与自2018年以来收集的yEvo数据进行比较.
主要成果:
- yEvo突变浏览器有效地可视化突变基因及其位置.
- 它对突变类型进行分类,并有助于识别表型相关突变.
- 该工具有助于对不同实验进化数据集进行比较.
结论:
- yEvo突变浏览器简化了从实验进化的遗传适应数据的解释.
- 它增强了学生对生物体如何通过遗传变化适应环境压力的理解.
- 该工具对研究和教育中的其他模型生物有潜在的应用.
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