认知过程在整个皮层的尺度上脱而出
Renan M Costa1, Jiaqi K Luo1, Peter S Salvino1
1Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago IL USA.
bioRxiv : the preprint server for biology
|August 8, 2025
概括
研究人员发现,大脑中不同的认知过程在皮层中脱而出. 这个组织支持准确的决策,但在错误时会崩.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 计算神经科学是一种神经科学.
背景情况:
- 决策依赖于多个认知过程.
- 这些过程分布在皮层中,但通过区域内的直角人口活动模式来实现.
- 整个皮质的局部神经几何体的整合仍然不清楚.
研究的目的:
- 为了调查皮层范围内的神经动力学如何在决策过程中支持不同的认知过程.
- 确定神经活动的几何组织,代表感官证据的积累,短期记忆和选择.
主要方法:
- 为小鼠开发了一个虚拟导航任务,以分离证据积累,记忆和选择.
- 利用大脑皮层范围的广场 (Ca2+) 成像.
- 应用缩小维度和解码模型来分析神经群体活动.
主要成果:
- 观察到分布式但近直角的编码子空间,用于不同的认知过程 (证据积累,记忆,选择).
- 在错误的选择过程中,这种神经几何分解.
- 记忆子空间,但不是其他人,与自发活动时间尺度层次结构保持一致,表明内在电路属性的选择.
结论:
- 支持不同认知过程的整个皮层的神经动力学被解开.
- 这种解对于准确的决策至关重要,并且在错误时会崩.
- 记忆子空间与内在电路属性的对齐表明了其集成到决策计算中的机制.
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