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相关概念视频

Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.9K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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Forced Transdifferentiation01:28

Forced Transdifferentiation

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Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
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相关实验视频

Updated: Sep 12, 2025

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
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Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

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错位的小鼠Pax6内部神经元子类:一种跨物种的转录基因重新分配.

Jonathan M Werner1, Hamsini Suresh1, Jesse Gillis1

  • 1Physiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.

bioRxiv : the preprint server for biology
|August 8, 2025
PubMed
概括

在小鼠中发现了一种在哺乳动物中保存的新型Pax6内部神经元子类,挑战了以前的图谱. 这一发现强调了神经科学研究中需要对进化有意识的比较分析的需要.

科学领域:

  • 神经科学是一个神经科学.
  • 基因组学就是基因组学.
  • 进化生物学 进化生物学

背景情况:

  • 哺乳动物大脑的细胞类型保护已经得到了很好的证实.
  • 之前的小鼠转录图集意外地显示出缺少尾部质突出 (CGE) Pax6内部神经元子类.

研究的目的:

  • 在小鼠大脑图谱中识别和描述一个缺失的Pax6内部神经元子类.
  • 为了研究哺乳动物内部神经元子类的进化分歧.
  • 开发用于跨哺乳动物比较转录学的改进方法.

主要方法:

  • 跨物种的转录基因分析.
  • 进行比较的基因组学.
  • 转录图谱的生物信息分析.

主要成果:

  • 在小鼠大脑中发现了一种Pax6内部神经元子类同类物.
  • 在Sncg亚类中观察到灵长类特定的分歧.
  • 这项研究揭示了依赖单个标记基因进行细胞类型识别的局限性.

结论:

  • 这些发现需要更新关于Pax6内部神经元子类的小鼠大脑地图.

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Radioactive in situ Hybridization for Detecting Diverse Gene Expression Patterns in Tissue
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Last Updated: Sep 12, 2025

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  • 具有进化意识的注释和标记集对于准确的跨哺乳动物内部神经元比较至关重要.
  • 这项研究强调了在转录组学研究中考虑进化史的重要性.