维生素C生物合成的损失可以防止寄生虫感染
Gongwen Chen1, Ji Hyung Jun2, Tobias Wijshake2
1State Key Laboratory of Genetics and Development of Complex Phenotypes, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
bioRxiv : the preprint server for biology
|August 8, 2025
概括
阿斯科伯酸盐 (维生素C) 缺乏会保护小鼠免受一种寄生虫疾病 - - 杆菌病的侵害. 这一发现表明,某些维生素缺乏可能会对依赖宿主维生素的病原体提供保护.
科学领域:
- 进化生物学是进化的生物学.
- 寄生虫学的寄生虫学
- 营养科学 营养科学
背景情况:
- L-Gulonolactone Oxidase (GULO) 合成亚斯酸盐 (维生素C),但在一些动物系中已经丢失.
- 缺乏GULO的动物,包括人类,需要饮食中含有酸,容易患病.
- GULO的进化损失通常被认为是中性的,但潜在的好处尚未被探索.
研究的目的:
- 调查失去了甲酸盐的合成是否赋予任何生理上的优势.
- 测试GULO缺乏提供对寄生虫感染的保护的假设.
主要方法:
- 缺乏GULO的小鼠接受了不同水平的 Askorbate.
- 用 Schistosoma mansoni 的感染模型来评估疾病进展和病理学.
- 分析了 Askorbate 对类细胞卵子产生影响的机制,包括基因素去甲基化.
主要成果:
- 阿斯科伯缺乏症显著地保护了小鼠免受杆菌病的侵害.
- 杆虫 (Schistosoma mansoni) 需要宿主酸盐来在体内产生卵子.
- 缺甲酸盐的小鼠显示病理学和转移的降低了杆菌病.
- 间歇性 Askorbate 缺乏在 Gulo 缺乏的小鼠中预防了皮病和杆菌病的死亡率.
- 亚斯科巴酸盐对分裂体繁殖的影响与基因素脱甲基化和白细胞发育有关.
结论:
- 亚酸盐缺乏提供了对杆菌病的保护.
- 宿主维生素的可用性对于某些寄生虫生命阶段至关重要.
- 维生素缺乏可能通过保护特定病原体而带来进化优势.
- 这挑战了维生素缺乏仅仅是有害的观点.
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