双特征选择性使视觉皮层神经元的双向编码成为可能
Katrin Franke1,2,3,4, Nikos Karantzas1,2,3, Konstantin Willeke1,2,3
1Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Stanford, CA, US.
bioRxiv : the preprint server for biology
|August 8, 2025
概括
视觉皮层中的神经元使用双重特征策略,对增强和抑制刺激作出反应. 在和小鼠视觉皮层中的这一发现表明神经编码比以前理解的更复杂.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 视觉皮层研究 视觉皮层研究
背景情况:
- 传统观点:感官神经元作为简单的特征探测器,增加首选刺激的发射率.
- 对于超出基本刺激的复杂神经编码策略的有限理解.
- 需要探索神经元如何同时编码多个刺激特性.
研究的目的:
- 在视觉皮层中识别和描述一种新的双特征编码策略.
- 研究这种策略在神经群体对视觉信息编码中的作用.
- 探索这种编码机制的跨物种和跨区域保护.
主要方法:
- 在的视觉区域V1和V4中的神经元记录.
- 开发和应用功能数字双胞胎模型 (基于深度学习的预测模型).
- 在自然图像相似空间中沿连续轴进行神经元活动的分析.
主要成果:
- 发现神经元被选择性调节为两个不同的视觉特征:一个增强和一个抑制活动.
- 在图像空间中确定连续的低维轴,其中神经元活动差异大约是线性的.
- 在神经元群体中共享特征选择性的证据,结构化刺激编码.
- 保护跨物种 (和老鼠) 和视觉区域 (V1,V4,主要和侧面区域) 的双特征选择性.
结论:
- 神经元采用复杂的双特征编码策略,涉及刺激和抑制.
- 这一策略增加了神经元群体的代表性能力.
- 这些发现与特征特异性抑制连接的解剖学证据一致.
- 双特征选择性是视觉皮层的一个基本编码原理.
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