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Updated: Sep 12, 2025

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
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A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

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动蛋白调节的核形状控制癌症相关纤维细胞的适应性重编程

Jie Wang, Bruna da Silva Soley, Yao Xiao

    bioRxiv : the preprint server for biology
    |August 8, 2025
    PubMed
    概括

    BRAF抑制剂通过诱导核变形来重编程与癌症相关的纤维细胞 (CAF),促进核β-catenin的积累. 这种机械过程由ROCK信号介导,改变了瘤微环境中的CAF转录活性.

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    Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology06:54

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