独特的神经性路径塑造了皮层输出通道的多样化和马赛克组织
Shreyas M Suryanarayana1,2, Xu An1,2, Yongjun Qian1,3
1Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.
bioRxiv : the preprint server for biology
|August 8, 2025
概括
两种不同的神经生成途径塑造了哺乳动物的大脑电路. 间接神经发生 (iNG-ETi) 放大和多样化直接神经发生 (dNG-ETd) 的投影,创建复杂的皮质输出通道.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 遗传学 遗传学 是一个
背景情况:
- 哺乳动物大脑皮层依赖于外脑神经元 (ET) 进行多种不同的投射到下皮层区域.
- ET神经元来自两个途径:直接的神经发生 (dNG-ETd) 和间接的神经发生 (iNG-ETi).
- ETd和ETI对皮质输出组织的独特贡献仍然基本上是未知的.
研究的目的:
- 研究直接和间接神经发生路径对哺乳动物皮层输出通道组织的差异性贡献.
- 阐明这两种神经性路径是如何影响外脑外投射的多样化和特异性的.
主要方法:
- 在小鼠中利用一种基于血统的新型遗传策略,在同一动物中对ETd和ETI神经元的差异性病毒接入.
- 在皮层中比较ETd和ETI群体的投影模式和目标特异性.
主要成果:
- 间接神经发生 (iNG-ETi) 显著放大和多样化来自直接神经发生 (dNG-ETd) 的预测.
- ETd投射主要局限于前脑和中脑结构,而ETI神经元则广泛地刺激后脑和脊髓.
- ETI神经元产生新的投射类型,并表现出特定区域的模式,包括由产后修剪雕塑的脊髓内.
结论:
- 两个基本的神经源途,dNG-ETd和iNG-ETi,以不同的方式塑造皮质输出通道的区域特定多样化和组织.
- 间接神经发生在扩大皮质突出的多样性和范围方面发挥着至关重要的作用,特别是在后脑和脊髓.
- 进化的独特的神经性路径有助于哺乳动物大脑电路的复杂,马赛克式组织.
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