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使用生物层干涉测量的抗病毒化合物的表征

Zachary C Lorson1,2, William M McFadden1,2, Grace Neilsen1,2

  • 1Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive NE, Atlanta, GA.

bioRxiv : the preprint server for biology
|August 8, 2025
PubMed
概括

优化的生物层干扰测量 (BLI) 协议有效地描述了用于抗病毒发现的小分子-蛋白相互作用. 这种高通量方法克服了常见的陷,使药物开发的精确亲和度测量成为可能.

关键词:
生物层干涉测量 (BLI) 是一种生物层干涉测量.生物分子相互作用卡普西德蛋白 (CA) 是一种人类免疫缺陷病毒 (HIV)莱纳卡帕维尔 (LEN) 是一种主要蛋白质酶nsp5尼尔马特雷尔维尔 (NIR) 是一种药物.严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2)

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