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Updated: Jul 8, 2026

Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks
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ProtLoc-GRPO:使用基于图形的模型和强化学习的细胞系特定亚细胞局部化预测

Shuai Zeng1,2, Weinan Zhang1,2, Chaohan Li2

  • 1Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.

bioRxiv : the preprint server for biology
|August 8, 2025
PubMed
概括

我们开发了ProtLoc-GRPO,一种新的强化学习方法,通过优化蛋白质-蛋白质相互作用网络来改善细胞系特异性蛋白质亚细胞局部化预测. 这种方法通过改进网络结构以获得更好的生物见解来提高准确性.

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相关概念视频

End Point Prediction: Gran Plot01:07

End Point Prediction: Gran Plot

A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
For potentiometric titration, the Gran plot is created by plotting the...