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在复发性/持久性分化甲状腺癌中检测到远程转移和重新手术后的无塑性转变的临床风险因素:一项回顾性队列研究
Min-Su Kim1, Yung Jee Kang2, Soon-Hyun Ahn2
1Department of Otorhinolaryngology-Head and Neck Surgery CHA Bundang Medical Center, CHA University School of Medicine Seongnam Republic of Korea.
Laryngoscope investigative otolaryngology
|August 8, 2025
概括
远程转移和厌塑性转变发生在重复的分化甲状腺癌在重新手术后. 诸如男性性别,年龄较大,先进的初始阶段和多次重复手术等因素增加了这些不良结果的风险.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 手术瘤学手术瘤学
背景情况:
- 复发性/持久性差异化甲状腺癌带来了挑战,对远程转移或术后形转变的研究有限.
- 了解风险因素对于管理这些高级病例至关重要.
研究的目的:
- 在差异化甲状腺癌患者重新手术后,确定与远程转移或形转变相关的临床因素.
- 为了告知风险分层和治疗策略的重复性甲状腺癌.
主要方法:
- 对336名因差异化甲状腺癌接受重新手术的患者的回顾性审查.
- 临床因素的分析和危险比率 (HRs) 和95%置信区间 (CI) 的估计,用于远程转移和亚塑性转变.
主要成果:
- 在13.4%的患者中检测到远程转移;风险随着男性性别,年龄≥55,初始T3-4阶段,现场复发和≥3次重复手术而增加.
- 在2.1%的患者中检测到无塑性转变;风险随着年龄≥55岁和≥3次重复手术而增加.
结论:
- 远程转移和形转变是重复的分化甲状腺癌术后复发的重大问题.
- 识别高风险患者 (男性,≥55岁,初始T3-4阶段,多次重复手术) 对于量身定制的管理至关重要.
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