在注射粒细胞殖民地刺激因子后的风炎:一个病例报告.
Shuichi Fujiwara1, Hitomi Hara1, Naomasa Fukase1,2
1Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
Biomedical reports
|August 8, 2025
概括
颗粒细胞殖民地刺激因子 (G-CSF) 可以导致急性风炎. 本案例研究详细介绍了一名患者,在接受化学疗法后接受G-CSF pegfilgrastim 治疗后发生了主脉炎.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 颗粒细胞群刺激因子 (G-CSF) 刺激白血细胞的产生.
- G-CSF经常用于缓解化疗后的中性质减退症.
- 中性贫会增加感染风险,并可能导致发烧性中性贫.
研究的目的:
- 报告一种罕见的急性主动脉炎病例,可能是由G-CSF引起的.
- 为了突出G-CSF在癌症患者中的可能不良影响.
主要方法:
- 一个59岁的男性患者的病例报告.
- 患者因肝转移的圣骨胆瘤接受了埃里布林化疗.
- 佩格菲尔格拉斯蒂姆 (一种G-CSF) 用于中性质衰竭.
主要成果:
- 患者发烧,腹部疼痛,以及G-CSF后炎症标志物升高.
- 影像检查显示,主动脉炎影响脑动脉和腹部主动脉.
- 停用G-CSF后症状消失,这表明存在因果关系.
结论:
- 使用G-CSF可能会导致急性主动脉炎.
- 这种罕见的不良事件需要在出现相关症状的患者中考虑.
- 建议进一步调查G-CSF诱导的血管炎.
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