进行手术取精的加密动物精子患者的临床结果
Raneen Sawaid Kaiyal1, Rossella Cannarella1, Shinnosuke Kuroda1
1Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Urology Department, Cleveland, OH, United States.
Frontiers in urology
|August 8, 2025
概括
微切割丸精子提取 (microTESE) 为加密动物精子男性提供了高的成功率,这些男性的细胞内质精子注射 (ICSI) 失败. 这种手术性精子采集方法提供了一种可行的选择,以最小的并发症实现怀孕和活产.
科学领域:
- 生殖医学 生殖医学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 遗传学 是一个遗传学.
背景情况:
- 根据世卫组织的定义,加密动物精子症涉及射精中的稀有精子,由于精子质量差,往往导致细胞内质精子注射 (ICSI) 失败.
- 丸精子采集是考虑的加密动物精子男性失败的ICSI或不足的精液质量.
研究的目的:
- 评价微剖析丸精子提取 (microTESE) 的疗效和成功预测因子,在之前ICSI失败或精液质量差的加密动物精子患者中.
主要方法:
- 对于接受微TESE (2007-2021) 的加密动物种子患者的电子病历的回顾性审查.
- 评估人口统计,手术前实验室,病理学,精子检索率 (SRR) 和ICSI结果.
- 分析包括ICSI失败或精液质量不合适的患者.
主要成果:
- 在28名患者中,在81.0% (30/37) 的microTESE手术中,成功地获得了ICSI的运动精子.
- 50% (14/28) 的患者实现了阳性怀孕,42.8% (12/28) 的患者成功活产.
- 低精子发生是最常见的病理 (65.3%);纤维化与负面妊娠结果相关. 没有报告任何并发症.
结论:
- 微TESE是一种可行的和安全的手术精子采集选项,用于ICSI失败的加密动物精子男性,显示出高怀孕和活产率.
- 这种方法为因加密动物精子和排泄精子质量问题而面临不孕症的男性提供了有价值的替代方案.
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