除了通常的嫌疑人之外:微生物组年龄中的新兴泌尿病原体
Robert B Moreland1, Brian I Choi1, Wilson Geaman1
1Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, United States.
Frontiers in urology
|August 8, 2025
概括
新的文化独立方法揭示了多样化的尿路微生物群,挑战了诊断尿路感染 (UTI) 的传统方法的狭窄重点. 这表明,包括细菌在内的更广泛的微生物,可能会导致尿路感染症状.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 人的泌尿道包含一个复杂的微生物群落,即尿道微生物群.
- 标准的临床微生物学方法专注于一组有限的已知的尿病原体,可能会忽视其他致病原体.
- "没有生长"培养的患者的反复发生的尿路感染 (UTI) 和症状表明目前的诊断方法是不够的.
研究的目的:
- 通过先进的培养独立方法识别的新兴和可疑的尿病原体进行审查.
- 突出传统的基于培养的诊断在捕捉尿道微生物组的全谱方面的局限性.
- 刺激对被低估的微生物在尿路健康和疾病中的作用的研究.
主要方法:
- 利用了增强培养 (元文化) 和文化独立的基于DNA的 (元遗传) 技术.
- 分析了患有下尿路症状的患者的尿样.
- 通过先进的方法检测到的微生物物种,但被标准培养遗漏的文献.
主要成果:
- 超基因组和超文化组方法已经在尿路中发现了数百种微生物,远远超过了标准方法检测到的微生物.
- 常常被传统文化遗漏的快速生长,缓慢生长或无氧微生物,在患有尿路感染症状的患者中经常被检测到.
- 其中一些新发现的微生物也与非尿路感染有关,这表明机会性致病性.
结论:
- 目前对狭窄范围的泌尿病原体的关注可能对于诊断和理解尿路感染来说过于有限.
- 先进的分子技术对于揭示尿道微生物群的真正多样性及其在健康和疾病中的作用至关重要.
- 需要进一步的研究,以了解新出现的尿病原体的生物学及其从开始性转变为病原体的转变.
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