免疫疗法在抵抗割的前列腺癌的知识映射:一个图书统计和可视化研究 (2003-2022)
Xianfu Cai1,2, Chenguang Ding1, Yang Li1
1Department of Renal Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Frontiers in urology
|August 8, 2025
概括
图书统计分析显示,割抗性前列腺癌的免疫疗法取得了快速进展. 关键趋势包括检查点封锁和疫苗,美国和中国领导研究.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 图书统计学 图书统计学
背景情况:
- 抗割前列腺癌 (CRPC) 仍然是瘤学中的一个重大挑战.
- 免疫疗法已成为CRPC的有希望的治疗方式.
- 了解研究环境对于推进CRPC免疫疗法至关重要.
研究的目的:
- 为CRPC文献进行免疫治疗的文献分析.
- 为了可视化研究进展,并确定两个十年 (2003-2022) 的新兴趋势.
- 突出这一领域的关键贡献者和有影响力的机构.
主要方法:
- 在科学网络核心集合数据库 (2003-2022) 上进行文献搜索.
- 使用CiteSpace,Bibliometrix和VOSviewer软件进行图书统计分析.
- 在排除无关研究后,选择了373篇相关出版物.
主要成果:
- 在CRPC免疫疗法领域正在经历快速发展.
- 美国有显著的早期优势,而中国国家癌症中心最近表现强.
- 顶级机构包括UCSF,华盛顿大学和MSKCC;主要作者包括Gulley,Drake和Fong.
- 突出的研究趋势包括膜抗原表达,CTLA4阻断,-223和疫苗.
结论:
- 在CRPC免疫疗法的关键研究趋势是膜抗原表达,CTLA4阻断,-223和疫苗.
- 未来的研究很可能会专注于探索新的免疫路径和组合疗法.
- 有机体模型的进步可能会进一步加速CRPC免疫疗法研究.
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