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在受控的人类感染模型中对剂量升级的季节性流感H3N2病毒进行有效的气溶注射

Nadine Rouphael1, Ralph Tanios1, Jessica Traenkner1

  • 1Hope Clinic, Division of Infectious Diseases, Department of Medicine, Emory University; Decatur, GA, USA.

medRxiv : the preprint server for health sciences
|August 8, 2025
PubMed
概括

气溶输送系统在人类挑战模型中安全有效地模拟自然流感感染,为研究病毒和评估新治疗方法提供比传统的鼻内输送方法更准确的研究平台.

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Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...