强迫症障碍中的皮层和皮下结构变化:全球强迫症研究中的形态学和临床资料之间的关系
Niels T de Joode1,2, Chris Vriend1,2, Petra J W Pouwels3,4
1Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, and Department of Anatomy and Neuroscience, de Boelelaan 1117, Amsterdam, the Netherlands.
medRxiv : the preprint server for health sciences
|August 8, 2025
概括
强迫症 (OCD) 与特定的大脑结构变化有关,特别是在轨道前皮层和胰岛,与症状严重程度和并发症相关. 这些发现突出了参与强迫症病理学的关键大脑区域.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 大脑解剖学 大脑解剖学
背景情况:
- 强迫症 (OCD) 是一种复杂的神经精神疾病.
- 了解强迫症的神经生物学基础对于开发有效治疗方法至关重要.
研究的目的:
- 为了研究强迫症患者的皮层和皮层下大脑变化.
- 探索大脑形态与强迫症的临床特征之间的关系.
主要方法:
- 利用T1加权的MRI扫描,从266名没有药物的成年人中获得了强迫症和254名健康对照.
- 使用FreeSurfer的ROI指标和基于voxel的形态测量 (VBM) 来分析大脑结构.
- 在所有分析中,对年龄,性别,智商和研究地点进行控制.
主要成果:
- 在OCD和对照组之间,皮层厚度,表面积或皮层下体积没有显著的整体差异.
- 强迫症的严重程度与轨道前皮层 (OFC) 和内侧皮层 (insula) 的表面积减少相关.
- 特定的症状尺寸 (伤害/侵略,性/宗教) 和并发症 (抑郁症) 与大脑形态的明显变化有关.
结论:
- 强迫症中的结构性大脑变化与疾病严重程度,症状尺寸和并发性疾病有关.
- OFC和insula是关键的大脑区域,与强迫症病理生理学有关.
- 研究结果表明,强迫症的潜在并发症特异性神经解剖学变化.
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