系统性并发症与牙周炎严重程度的剂量依赖性关联:一项大型人口横截面研究
Muhammad H A Saleh1, Hamoun Sabri1
1Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Journal of periodontology
|August 8, 2025
概括
牙周炎的严重程度与系统性疾病的几率增加有关. 随着牙疾病的恶化,与糖尿病和艾滋病毒等疾病的关联变得更加明显,突出口腔健康问题.
科学领域:
- 口腔健康 口腔健康
- 牙周病学 牙周病学
- 公共卫生 公共卫生
背景情况:
- 牙周炎与各种系统性疾病有关.
- 牙周炎严重程度与全身健康之间的关系需要进一步研究.
- 电子健康记录 (EHR) 为研究这些关联提供了宝贵的资源.
研究的目的:
- 为了确定牙周炎和全身疾病之间的关联是否随着牙周炎的严重程度而增加.
- 分析不同程度的牙周炎严重程度和一系列系统性和行为性疾病之间的关联.
- 为了利用一个多中心的EHR存储库进行大规模分析.
主要方法:
- 对来自美国9所牙医学院的264,913名成年人 (2013-2023) 的电子病历数据进行横截面分析.
- 牙周炎的严重程度分为没有,轻度/中度或严重.
- 权重后勤回归评估了牙周炎和24种系统性疾病之间的关联,并根据年龄,性别,吸烟和糖尿病进行调整.
主要成果:
- 与轻度/中度牙周炎相比,严重的牙周炎在大多数系统性疾病中显示出持续较高的几率比率 (ORs).
- 例如,在严重牙周炎中,吸烟 (5.21对1.78),糖尿病 (5.59对2.20),艾滋病毒 (4.07对2.25) 和阿尔茨海默病 (3.20对1.84) 的OR显著增加.
- 反向相关性,就像喘一样,也随着牙周炎的严重程度的增加而加强.
结论:
- 牙周炎的严重程度与其与全身疾病相关的强度直接相关.
- 随着牙周炎的进展,与全身健康的积极和消极关联变得更加明显.
- 这些发现强调了综合医疗和牙科护理对患有慢性疾病的患者的重要性.
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