EXPRESS:与慢性疼痛和纤维肌痛类似症状相关的危险因素 后COVID住院治疗
Linamara Battistella1, Marta Imamura1, Xinyi Christine Zhang2,3
1Instituto de Medicina Física e Reabilitação, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Molecular pain
|August 8, 2025
概括
后COVID综合征可能导致慢性疼痛和纤维肌痛. 关键的危险因素包括焦虑,抑郁,失眠和肌肉衰弱,这些因素在住院的COVID-19幸存者中被发现.
科学领域:
- 神经学 神经学
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID综合征 (PCS) 呈现出慢性疼痛和纤维肌痛类似的症状.
- 这些长期后果的危险因素尚未得到充分了解.
研究的目的:
- 在住院COVID-19患者中确定慢性疼痛和纤维肌痛表型的预测因素.
- 调查释放后2-3年的长期结果.
主要方法:
- 756名住院COVID-19患者的前性队列研究.
- 数据收集后3-11个月 (第一阶段) 和2-3年 (第二阶段) 的数据.
- 多变量逻辑回归分析了慢性疼痛和纤维肌痛的预测因素.
主要成果:
- 焦虑/抑郁症的严重程度和左手握力的降低预测了慢性疼痛.
- 左侧疼痛,失眠和左手握力较弱预测了与纤维肌痛相关的结果 (CWP,FLS,FM).
- 纤维肌痛表型的显著概率比率在1.07至1.44之间.
结论:
- 心理困扰,睡眠障碍和肌肉衰弱是PCS疼痛的关键可修改的危险因素.
- 针对这些因素的早期干预可以改善长期结果.
- 这些发现为后COVID慢性疼痛和纤维肌痛的管理策略提供了信息.
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