性别和青春期状态与喘息,喘和肺功能发育的关系在基于多民族人口的前性队列中
Marina Attanasi1,2,3, Annemiek Mian1,2, Tarik Karramass1,2
1The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Pediatric pulmonology
|August 8, 2025
概括
性和青春期影响儿童的呼吸系统健康. 女孩的喘息风险较低,而青春期对男性和女性的肺功能都有积极的影响,受到体重指数和过敏的改变.
科学领域:
- 儿科呼吸系统医学 儿科呼吸系统医学
- 环境流行病学环境流行病学
- 人类成长和发展 人类成长和发展
背景情况:
- 性和青春期的发展是影响生理变化的关键因素.
- 了解它们对儿童呼吸系统健康的影响对于有针对性的干预措施至关重要.
- 之前的研究还没有完全阐明这些不同人群之间的关联.
研究的目的:
- 调查性别和青春期与儿童呼吸系统健康结果之间的关联.
- 为了确定种族,体重指数 (BMI) 或过敏敏感性是否会改变这些关联.
- 评估青春期发育对肺功能指标的影响.
主要方法:
- 这是一项针对3418名儿童的基于人口的多民族队列研究.
- 通过医疗记录 (性别) 和问卷 (青春期阶段,喘息,喘) 收集的数据.
- 青春期阶段使用坦纳阶段进行分类;在13岁时进行螺旋测量.
主要成果:
- 女孩表现出持续较低的喘息风险 (OR 0.86),过敏女孩患喘风险较低 (OR 0.66).
- 体重不足和超重/肥胖的女孩分别表现出较低和较高的肺功能 (FEV1,FVC) Z-分数.
- 晚期青春期发育 (乳房,生殖器,阴毛) 与两性肺功能改善有关 (FEV1,FVC,FEF75).
结论:
- 呼吸系统发病风险因性别而异,受BMI和过敏敏感度的影响,但不是种族.
- 青春期对男孩和女孩的肺功能有积极的影响.
- 研究结果强调了在儿科呼吸系统健康中考虑性别和青春期状态的重要性.
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