量化抗生素处方在儿童与气管切除术
Rebecca Steuart1, Austin Slone2, Joshua Courter3
1Department of Pediatrics, Section of Complex Care, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
带有气管切除术的儿童受到显著的全身抗生素暴露,主要是广谱药物. 慢性呼吸机使用与此儿科群体抗生素处方减少相关.
科学领域:
- 儿科肺病学 儿科肺病学
- 传染病 传染病 传染病
- 抗微生物药物管理管理
背景情况:
- 气管切除术的儿童往往需要复杂的医疗护理.
- 这种脆弱人群的抗生素处方模式并未得到很好的描述.
研究的目的:
- 量化和表征系统性抗生素在儿童与气管切除术的使用.
- 为了确定与较高的抗生素处方相关的因素.
主要方法:
- 在548名带有气管切除术 (2个月18岁) 的儿童中进行了回顾性队列研究.
- 记录和分析了抗生素疗程和治疗日 (DOT).
- 多变量分析确定了抗生素处方的预测因素.
主要成果:
- 中位数的抗生素暴露是4个疗程和每年每名儿童33.8个DOT.
- 大多数抗生素疗程 (72.7%) 是广泛的.
- 从2010年到2018年,抗生素处方减少了30-33%.
- 风机使用与较低的DOT有关;更高的复杂性和ICU日与更高的DOT有关.
结论:
- 气管切除术的儿童表现出大量的全身抗生素使用,主要是广谱药物.
- 慢性呼吸机使用与抗生素处方减少有关.
- 调查结果可以为这一群体提供抗菌药物管理干预措施的信息.
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