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乳腺癌的3D体外模型:当前的挑战和未来的前景,重述微环境和模仿关键过程

Kyndra S Higgins¹, Ah Joung Yu¹, Cheryl T Gomillion¹

¹School of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, 30602, USA.

Advanced biology

|August 8, 2025

概括

开发先进的乳腺癌模型对于理解转移和改善患者治疗结果至关重要. 这些3D体外模型通过模仿瘤微环境来帮助发现向治疗方法.

科学领域:

在瘤学瘤学.
生物医学工程生物医学工程
癌症研究癌症研究

背景情况:

乳腺癌导致全球显著的死亡率,转移是死亡的主要驱动因素.
超过90%的乳腺癌死亡是由转移引起的,这凸显了迫切需要更好的研究模型.
目前的研究需要对主要瘤和转移部位的生理学相关模型.

研究的目的:

审查和强调用于研究乳腺癌原发性瘤环境的3D体外模型.
强调重复瘤微环境和癌细胞入侵的模型的重要性.
讨论这些模型在推进乳腺癌治疗策略方面的潜力.

主要方法:

使用瘤球体来创建三维细胞培养.
使用3D打印生物材料来设计类似组织的结构.
利用微流体设备来模拟生理条件.
专注于研究细胞入侵和乳腺组织内传播的模型.

主要成果:

多种3D体外模型有效地回顾了瘤微环境的各个方面.
这些模型有助于理解瘤异质性和细胞入侵的来源.
先进的模型可以针对患者进行特定的,这可能会减少对人体试验的需求.

结论:

有效的3D体外模型对于研究乳腺癌转移至关重要.
这些模型有助于发现针对乳腺癌的向治疗方法.
改进的体外建模将推动临床治疗策略和患者生存率的提高.

关键词:

通过3D打印打印3D打印.生物材料是一种生物材料.乳腺癌转移的发生.微流体学在微流体学方面瘤球形状的球形状

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