儿科牙科的再生策略:从过去到未来的组织工程的全面概述
Belen Şirinoğlu Çapan1, Sinem Birant1, Burak Gümüştaş2
1Faculty of Dentistry, Department of Pediatric Dentistry, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Advances in experimental medicine and biology
|August 8, 2025
概括
儿童牙科的组织工程利用生物材料,干细胞和生长因子再生儿童的牙组织. 这种方法为不成熟的牙提供了传统治疗方法的最小侵入性替代方案.
科学领域:
- 儿科牙科 儿科牙科
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
背景情况:
- 儿童牙科的组织工程旨在再生儿童受损的牙组织,恢复不成熟牙的功能.
- 它利用跨学科的生物原理,生物材料,干细胞和生长因子来进行组织修复和再生.
- 儿科牙科护理的挑战包括未成熟的牙结构和对最小侵入性治疗的需求.
研究的目的:
- 审查目前用于儿科牙科应用的组织工程的进展.
- 突出生物材料,干细胞和生长因子在再生牙-真菌复合物和牙结构中的作用.
- 讨论3D生物打印等新兴技术在儿科再生牙科中的潜力和挑战.
主要方法:
- 关于儿童牙科组织工程的当前文献的综述.
- 专注于生物材料 (例如原),生长因子 (FGF,TGF-β,BMP,VEGF) 和干细胞 (DPSC,SHED,PDLSC).
- 探索包括基因疗法,脚手架和3D生物打印在内的先进技术.
主要成果:
- 像原蛋白这样的生物材料在组织工程中为细胞生长提供结构支持.
- 增长因子调节信号通路,这对于牙-肉复合物的再生至关重要.
- 牙科衍生干细胞显示出在儿科患者中再生硬和软牙组织的显著潜力.
结论:
- 组织工程正在彻底改变儿科牙科治疗,特别是再生性内牙科.
- 它为年轻,不成熟的牙提供了传统根管治疗的微创替代方案.
- 未来的方向包括增强干细胞疗法和生物活性材料,以实现完整的组织再生和个性化的儿科牙科护理.
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