欧洲生物制药的引入:对早期扩散模式和数据可用性的跨部门研究
Ivar Veszelei1, Brian Godman2,3,4, Katri Aaltonen5,6
1Department of Pharmacy, Faculty of Pharmacy, Uppsala University, Box 580, 751 23, Uppsala, Sweden.
概括
欧洲国家在生物制药的采用和可用于监测其使用的数据的可用性方面表现出显著的差异. 需要进一步的研究,以确保在欧洲范围内获得公平和成本效益的药物.
科学领域:
- 药物经济学 药物经济学
- 医疗保健服务研究 医疗服务研究
- 相对的有效性比较
背景情况:
- 生物制药具有显著的治疗价值,但在欧洲医疗保健系统中存在临床和经济挑战.
- 跨国合作对于生物制药的可持续和公平引入至关重要.
- 关于欧洲国家早期引入生物制药的有限的比较研究存在.
研究的目的:
- 评估欧洲各国卫生当局数据的可用性.
- 分析生物制药在欧洲早期扩散的变化.
主要方法:
- 一项横截面研究分析了2015-2019年间批准的17种生物制药.
- 数据的可用性和传播率 (每1000名居民的确定的每日剂量) 被评估为2015-2022年.
- 相对国家排名是在市场授权后的最初4年内确定的.
主要成果:
- 20个国家/地区提供了关于生物制药利用的数据,其中20个国家/地区提供了医院外护理,15个国家/地区提供了批发和14个国家/地区提供了医院使用的数据.
- 观察到扩散率的显著变化,seukinumab和erenumab被广泛引入,而follitropin delta和tildrakizumab的吸收有限.
- 德国,奥地利和挪威的早期传播率最高,与立陶宛,罗马尼亚和拉脱维亚形成鲜明对比.
结论:
- 在生物制药的早期传播和数据的可用性,以监测其使用在欧洲各国存在实质性的差异.
- 需要进一步调查以了解这些模式的驱动因素.
- 优化生物制药的使用对于在欧洲实现公平和具有成本效益的药物获取至关重要.
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