低水平的环境一氧化碳暴露和血压:一个纵向面板研究在每小时的水平
Liyan Yang1, Zhi Yuan, Lin Miao
1Department of Toxicology, School of Public Health; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei 230032, China.
Journal of occupational and environmental medicine
|August 8, 2025
概括
暴露于环境一氧化碳 (CO) 会急剧增加大学生的血压 (BP). 这项研究强调了短期暴露于CO的心血管风险,特别是在女性和BMI异常的人群中.
科学领域:
- 环境健康 环境健康
- 心血管科学 心血管科学
- 毒理学 毒理学 毒理学
背景情况:
- 环境空气污染,包括一氧化碳 (CO),是严重的公共卫生问题.
- 了解CO暴露对心血管的急性影响对于公共卫生政策和个人风险评估至关重要.
研究的目的:
- 在一群大学生中调查环境一氧化碳 (CO) 水平和血压 (BP) 之间的直接关系.
- 为了确定受急CO暴露影响的特定血压参数和这些影响的时间进程.
主要方法:
- 一个小组研究设计,涉及40名大学生进行四次重复的健康检查.
- 测量压缩性血压 (SBP),压缩性血压 (DBP) 和平均动脉压 (MAP).
- 利用带有滞后期的线性混合效应模型来分析来自附近监测站的环境CO2数据与BP指标之间的关联.
主要成果:
- 升高的SBP,DBP和MAP与各种滞后期 (0-72小时至0-4天) 的环境CO暴露显著相关.
- 在暴露后7-12小时和25-48小时之间观察到CO对BP的单次滞后效应.
- 女性和身体质量指数异常的个体在应对CO暴露时表现出SBP更明显的增加.
结论:
- 对环境一氧化碳的急性暴露会引起亚临床的不良心血管影响.
- 观察到的血压升高是CO的直接心血管影响的生物标志物.
相关概念视频
Measurement of Blood Pressure
1.4K
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
1.4K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.6K
Chemical Factors Affecting Respiration Centers
1.3K
Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
CO2 has a potent influence on respiration and is strictly regulated....
CO2 has a potent influence on respiration and is strictly regulated....
1.3K
Factors affecting Blood pressure
4.8K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
4.8K
Physiological Control of Respiration
3.5K
Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
3.5K
Hypertension III: Clinical Manifestations and Diagnostic Studies
48
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
48


