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Updated: Sep 12, 2025

Detection of Copy Number Alterations Using Single Cell Sequencing
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Detection of Copy Number Alterations Using Single Cell Sequencing

Published on: February 17, 2017

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在癌症群体中推断拷贝数克隆的表型,使用TreeAlign

Hongyu Shi1, Matthew Zatzman1, Sohrab Shah1

  • 1Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Methods in molecular biology (Clifton, N.J.)
|August 8, 2025
PubMed
概括

这项研究介绍了TreeAlign,一种计算方法,将基因表达变化与单个细胞的拷贝数变化联系起来. 它使单细胞RNA测序和全基因组测序数据的联合分析能够用于癌症研究.

关键词:
癌症基因组学 癌症基因组学可能性的建模.单细胞RNA测序的一个细胞.单细胞全基因组测序瘤的进化过程瘤微环境是一个微环境.

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