游戏设置-MATCH:液体活检进入下一轮
Alessandro Russo1, Paola Muscolino2, Christian Rolfo3
1Humanitas Istituto Clinico Catanese, Misterbianco, Catania, Italy.
概括
液体活检显示与瘤基因型鉴定具有很高的一致性,用于检测基因组改变. 这支持其在针对性治疗试验中的使用,当组织活检是不可能的.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 分子诊断学 分子诊断
背景情况:
- 向治疗依赖于识别瘤中的特定基因组变化.
- 瘤基因型鉴定是检测这些变化的标准方法.
- 在获得足够的瘤组织以进行全面的基因组分析方面存在挑战.
研究的目的:
- 评估瘤基因型和血基因型之间的一致率.
- 评估液体活检在确定可用于向治疗的可操作基因组变化的有用性.
主要方法:
- 对瘤和血基因型化结果的比较分析.
- 使用下一代测序检测可操作的基因组改变.
主要成果:
- 在瘤和血基因型定型之间观察到高一致性.
- 液体活检有效地识别了与组织活检相比的关键基因组变化.
结论:
- 血基因型鉴定 (液体活检) 是组织基因型鉴定的一个可行的替代方案.
- 液体活检有助于患者参加基因组指导的临床试验,特别是当组织有限或无法获得时.
相关概念视频
01:17Colloids and Suspensions
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
01:13Excess Pressure Inside a Drop and a Bubble
The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops.
01:18Rise of Liquid in a Capillary Tube
When very thin cylindrical tubes, called capillaries, are dipped in a liquid, the liquid rises or falls in the tube compared to the surrounding liquid. This phenomenon is called capillary action. Capillary action occurs due to the combination of two opposing forces: the cohesive forces of the liquid, which cause it to stick to itself and form a rounded shape, and the adhesive forces between the liquid and the walls of the container, which cause the liquid to be attracted to the container walls.
01:11Glassware Calibration
Accurate calibration of glassware, such as volumetric flasks, pipettes, and burettes, is essential to ensure accurate measurements in the analytical laboratory. Calibration helps maintain consistency across measurements and prevents errors arising from inaccurate volumes.
Volumetric flasks: Volumetric flasks are designed to prepare aqueous solutions of precise volumes accurately with a calibration line on the neck. To calibrate a volumetric flask, it is important to fill it with distilled...
Volumetric flasks: Volumetric flasks are designed to prepare aqueous solutions of precise volumes accurately with a calibration line on the neck. To calibrate a volumetric flask, it is important to fill it with distilled...
01:27Two Components: Liquid–Liquid Systems
A pressure-composition phase diagram explicitly describes the behavior of an ideal solution of two volatile liquids under varying pressures and compositions. A pressure-composition diagram has two main curves. The bubble point curve represents the plot of pressure versus liquid mole fraction. It indicates the pressure at which the first bubble of vapor forms from the liquid phase as the system pressure decreases.The dew point curve is the pressure versus vapor mole fraction. It indicates the...
01:12Flow Table Test
The flow table test is an established method used to assess the workability of concrete, particularly useful for evaluating highly flowable concrete mixes. This test employs an apparatus that consists of a wooden board topped with a steel plate, collectively weighing 35 pounds. The board is connected to a base via a hinge and measures 27.6 inches on each side.
Concrete is placed within a truncated cone mold that is 8 inches high with an 8-inch base diameter and a 5-inch top diameter. The...
Concrete is placed within a truncated cone mold that is 8 inches high with an 8-inch base diameter and a 5-inch top diameter. The...