肺癌手术后的术后静脉血栓栓塞风险:一个系统性审查和元分析
Jing Chen1,2,3, Yuanzheng Mao1,2,3, Zhiyu Peng4
1Department of Emergency Medicine, West China Hospital, Sichuan University/ West China School of Nursing, Sichuan University, Chengdu, 610041, China.
Journal of thrombosis and thrombolysis
|August 8, 2025
概括
手术后静脉血栓栓塞 (VTE) 影响1.82%的肺癌手术患者. 晚年,更长的手术,开放胸切除术,晚期癌症,腺癌和重大切除增加了静脉突发症的风险.
科学领域:
- 胸部外科手术 胸部外科手术
- 在瘤学瘤学.
- 血管医学 血管医学
背景情况:
- 静脉血栓栓塞 (VTE) 是肺癌手术后的一种严重并发症.
- 确定术后风险因素对于预防VTE相关的发病率和死亡率至关重要.
研究的目的:
- 在接受肺癌手术的患者中识别与静脉瘤发展相关的术后风险因素.
- 为有针对性的血栓预防策略提供证据.
主要方法:
- 在PubMed和EMBASE数据库中进行系统的文献搜索 (截至2023年11月1日).
- 对11项研究 (53,382名患者) 的随机效应元分析,以确定风险因素的聚合发病率和几率比率 (ORs).
- 13项符合条件的研究的定性综合.
主要成果:
- 手术后静脉瘤的综合发病率为1.82%.
- 确定的重大风险因素包括晚年 (SMD 0.43),长时间的手术 (SMD 0.58),开放胸切除术 (OR 1.77),晚期TNM阶段 (OR 1.81),腺癌组织学 (OR 1.29) 和主要肺切除 (OR 1.51).
结论:
- 已经确定了肺癌手术患者手术后静脉瘤的关键可修改和不可修改的风险因素.
- 这些发现支持个性化风险分层和向性血栓预防,以改善患者的治疗结果.
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