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在非功能性垂体腺瘤中手术后进展的预测因素:西班牙多中心研究

Betina Biagetti^1,2, Andres Cardona-Arias³, Edelmiro Menéndez Torre⁴

¹Endocrinology & Nutrition Department, Hospital Universitario Vall de Hebrón, Universitat Autònoma de Barcelona, CIBERER U747 (ISCIII), EndoERN, Barcelona, Spain. betinaloys.biagetti@vallhebron.cat.

Journal of endocrinological investigation

|August 8, 2025

概括

非功能性垂体腺瘤 (NFPAs) 可以进展,特别是在15年内. 手术后的残留瘤和侵略性病理是非功能性垂体腺瘤进展的关键预测因素,指导长期患者监测.

科学领域:

内分泌学在内分泌学.
神经外科神经外科
在瘤学瘤学.

背景情况:

非功能性垂体腺瘤 (NFPAs) 呈现出不可预测的临床过程.
瘤复发和进展是管理NFPAs的重大挑战.

研究的目的:

评估NFPA患者的无进展生存期 (PFS).
在NFPA中识别瘤进展的预测因子和模式.

主要方法:

对472名NFPA大于1厘米的患者进行了回顾性多中心研究.
瘤进展以大小增加,成像生长或新的/恶化的症状来定义.
卡普兰-梅尔分析PFS和考克斯回归在手术队列中的进展预测指标.

主要成果:

14.2%的患者经历了中位数7.9年的瘤进展.
大多数进展事件 (89.6%) 发生在15年内.
残留瘤 (HR=5.1) 和侵略性组织病理学 (HR=2.1) 是进展的显著预测因素.

结论:

NFPA具有逐渐进展的风险,在最初的15年内达到顶峰.
术后残留瘤和侵略性组织病理学是最强的进展预测因素.
最大限度的安全切除和详细的组织病理学评估对于风险分层和长期监测至关重要.

关键词:

临床行为结果.不起作用的功能.下垂体腺瘤是什么意思没有进展的生存率.复发情况复发情况

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