通过同步剂量表来操纵癌症免疫循环
Saeedeh Mahmoodifar1, Kristina Stuckey2, Paul K Newton2,3,4
1Department of Physics and Astronomy, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA 90089-1191.
同步化疗和免疫疗法剂量与癌症免疫循环优化治疗. 战略定时,而不仅仅是剂量,可以提高疗效,减少癌症患者的毒性.
科学领域:
- 数学瘤学数学瘤学
- 系统生物学 系统生物学
- 进化游戏理论的演化游戏理论.
背景情况:
- 癌症的演变受到免疫反应和治疗压力的影响.
- 化疗和免疫疗法是具有复杂相互作用的关键癌症治疗方法.
- 优化治疗计划对于最大限度地提高疗效和最大限度地降低毒性至关重要.
研究的目的:
- 开发癌症免疫循环的数学模型.
- 调查化疗和免疫治疗的最佳组合,时间和剂量.
- 在竞争和时间依赖的选择压力下探索治疗策略.
主要方法:
- 开发了一种非线性动态系统,将癌症,健康和T细胞模拟为石头-纸-剪刀游戏.
- 综合化疗和免疫疗法作为控制功能与癌症免疫周期的基本时期同步.
- 分析了剂量计划,持续时间和顺序,以获得最佳的治疗结果.
主要成果:
- 化疗和免疫治疗的脉冲剂量计划不是交换性的.
- 化疗的最佳持续时间是癌症免疫周期的四分之一;免疫治疗是半个周期.
- 免疫治疗应该先进行化疗,并且持续两倍的时间,以改善结果.
结论:
- 优化化疗和免疫治疗剂量的时间可以提高治疗效率.
- 战略安排可以补偿较低的药物总剂量,减少毒性.
- 准确测量癌症免疫周期期对于临床应用至关重要.
更多相关视频
06:20Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
相关概念视频
Tumor Immunotherapy
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
