[多发性硬化症的当前流行病学,在儿童和青少年时期发病 (儿科多发性硬化症) ]
A N Boyko1,2
1N.I. Pirogov Russian National Research Medical University (Pirogov University), Moscow, Russia.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
|August 8, 2025
概括
儿童多发性硬化症 (MS) 在全球范围内呈现越来越高的流行率和发病率. 像fingolimod这样的新疗法为儿童多发性硬化症患者提供了改善的治疗方法.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 儿科 儿科 儿科
背景情况:
- 多发性硬化症 (MS) 在童年和青春期发病,称为儿科MS (PMS),具有独特的流行病学挑战.
- 了解PMS趋势需要分析不同国家和时间段的数据,并考虑方法差异.
研究的目的:
- 在全球范围内分析儿科MS (PMS) 的流行病学指标.
- 讨论PMS流行病学研究的挑战和解决方案.
- 介绍关于PMS的全球元分析和评论的发现.
主要方法:
- 对2000-2016年和2017-2025年PMS流行病学数据的分析.
- 考虑特定于儿科患者群体的方法特征.
- 包括来自全球元分析和综述的数据.
主要成果:
- 在全球范围内,儿童多发性硬化症 (PMS) 患病率显著增加.
- 孕前综合征的发病率也在上升,但比患病率要小.
- 数据表明,全球儿童多发性硬化症的负担越来越大.
结论:
- 儿科多发性硬化症 (PMS) 的患病率和发病率正在增加,这凸显出越来越多的公共卫生问题.
- 目前的治疗选择,包括fingolimod和像ofatumumab这样的抗B细胞药物,在管理PMS活动方面显示出希望.
- 持续的研究和改进的方法对于准确的PMS流行病学和有效的治疗策略至关重要.
相关概念视频
Psychological and Sociocultural Causes of Schizophrenia
187
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
187
Autism Spectrum Disorder
338
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
338
Prevalence and Incidence
812
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
812
Attention-Deficit/Hyperactivity Disorder
290
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
290
Biological Causes of Schizophrenia
149
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
149
Conduct Disorder
106
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
106


