协调药物分析和可持续性:对抗血小板抗凝剂方案的光谱量化
Nora A Abdallah1, Heba Elmansi1, Manal A Alossaimi2
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
概括
新的光谱学方法可以准确地确定药物和血中的阿皮克萨班,阿司匹林和克洛皮多格雷尔. 这些经过验证的分析技术提供了一种简单,有效的方法来测量这些关键的抗血栓剂.
科学领域:
- 分析化学 分析化学
- 药品分析 药品分析
- 频谱学是一种光谱学.
背景情况:
- 抗血栓剂,包括抗血小板和抗凝药,对于控制心血管疾病至关重要.
- 与阿皮克萨班,阿司匹林和克洛皮多格雷尔的联合治疗是为了降低心血管死亡风险而开出的.
- 在制药配方和生物样本中精确确定这些药物是必不可少的.
研究的目的:
- 开发新的,简单和准确的光谱方法,用于同时确定阿皮克萨班,阿司匹林和克洛皮多格雷尔.
- 根据ICH指南验证开发的方法.
- 评估拟议的分析程序的绿色性.
主要方法:
- 开发了三种光谱方法:直接测量,比率光谱和第一个导数比率光谱.
- 在310nm直接测量阿皮克萨班.
- 在各种矩阵中同时确定所有三种药物的比率和第一导数比率光谱.
主要成果:
- 使用开发的光谱方法,成功地同时确定了阿皮克萨班,阿司匹林和克洛皮多格雷尔.
- 方法在指定的度范围内显示出良好的线性 (阿皮克萨班为0.5-18微克/毫升,阿司匹林和克洛皮多格雷尔为2.0-28微克/毫升).
- 这些方法有效地应用于原材料,合成混合物,剂量形式和的人体血.
结论:
- 开发的光谱方法是可靠的,高效的,适合于同时量化阿皮克萨班,阿司匹林和克洛皮多格雷尔.
- 这些方法为药物和生物样本中药物分析提供了一种简化方法.
- 评估的绿色度表明了环保的分析程序.
相关概念视频
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
645
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
645
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.3K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.3K
00:59Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
124
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
124
01:15Drug Dosage Regimen: Overview
3.8K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.8K
01:23Drug Concentrations: Measurements
586
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
Plasma...
586
01:14Agonism and Antagonism: Quantification
566
When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
566