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Pedro Amado¹, Shaokai Zheng², Fiona Burkhard³

¹ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.

Computers in biology and medicine

|August 8, 2025

概括

尿管支架中的额外侧孔 (ASH) 可能会减少感染和阻塞等并发症. 优化ASH设计,特别是直径,可以改善流体动力学,并防止在正常流动和膀外流 (VUR) 期间形成生物膜.

科学领域:

生物医学工程生物医学工程
泌尿器科泌尿器科泌尿器科泌尿器科
流体动力学流体动力学

背景情况:

双J尿管支架对于维持尿流至关重要,但易受结,生物膜形成和感染的影响.
膀回流 (VESICOURETERAL REFLUX,简称VUR) 或反向尿流是一种显著的并发症,增加了感染风险和脏压力.
现有的支架设计在预防这些并发症方面存在局限性.

研究的目的:

调查支架末端的额外侧孔 (ASH) 的功能,重点关注VUR期间的性能.
评估ASH对流体动力学,壁切应力 (WSS) 和流通路径的影响.
探索不同的ASH直径如何影响支架性能和并发症预防.

主要方法:

使用计算建模来模拟尿路支架内的流体动力学.
分析重点是流通路径,壁切应力 (WSS) 和正常流动和VUR期间的流体交换.
模拟包括不同直径的ASH (0.7毫米,1毫米,1.2毫米).

主要成果:

在VUR期间,ASH在支架和尿管之间重新分配液体交换,改变WSS模式.
ASH直径显著影响WSS分布;较大的直径增加流体交换,但减少局部平均WSS.
降低局部平均WSS对于防止生物膜附着至关重要.

结论:

量身定制的ASH设计优化为缓解尿路支架并发症提供了一个有希望的方法.
ASH可能会降低与内置支架相关的感染,阻塞和脏压力的风险.
对ASH设计的进一步研究可能会导致改善患者的治疗结果.

关键词:

计算流体动力学计算流体动力学层和生物膜的形成.剪切压力压力是什么尿道支架尿道支架膀管回流 (Vesicoureteral reflux) 是一种引起人体反流的疾病.

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