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TRPA1的遗传多态性确实影响了中国人群中西斯产生的毒性风险

Cong Wang¹, Guifei Deng¹, Siyu Niu²

¹Department of Nephrology, Yibin Traditional Chinese Medicine Hospital. Yibin, Sichuan 644600, China.

Translational oncology

|August 8, 2025

概括

在TRPA1基因中,单核酸多态 (SNP) 与西斯胺诱导的毒性风险降低有关. 这些TRPA1SNP可以作为预测接受西斯治疗的患者损伤的生物标志物.

科学领域:

药物基因组学药物基因组学
腎臟病學 (nephrology) 是一種醫學專業.
在瘤学瘤学.

背景情况:

西斯普拉丁化疗可以导致不可逆转的急性损伤 (AKI),限制其临床应用.
短暂受体潜在蛋白1 (TRPA1) 通过NF-κB信号和炎症起作用,在西斯胺诱导的毒性 (CIN) 中发挥作用.
遗传变异,特别是TRPA1和NF-κB1基因中的单核酸多态 (SNPs),可能会影响个体对损伤的敏感性.

研究的目的:

研究TRPA1和NF-κB1基因中的特定SNP与西斯普拉丁诱导的急性毒性发生之间的关联.
确定潜在的遗传生物标志物,用于预测在接受基于西斯的化疗的患者中的毒性.

主要方法:

在TRPA1和NF-κB1基因中的17个SNP的基因定型,使用高通量SNP扫描技术.
分析了589名汉族肺癌患者的DNA,这些患者接受了西斯的治疗.
根据对不良事件的共同术语标准 (CTCAE 5.0) 评估毒性严重程度.

主要成果:

与C等位基因载体相比,TRPA1基因rs920829位点T等位基因载体的毒性风险显著降低 (OR 0.684,p=0.003).
对TRPA1 rs920829的附加和主导遗传模型也表明了保护作用.
研究的NF-κB1基因SNP与西斯胺诱导的毒性之间没有发现显著的相关性.

结论:

在TRPA1基因中的SNP,特别是rs920829位点,显示出潜在的预测生物标志物为西斯诱导的毒性.
进一步验证TRPA1SNP可能有助于个性化治疗策略,以减轻脏损伤.

关键词:

中国人口中国人口.西斯普拉丁的脏毒性遗传多形态的遗传多形态.暂时的受体潜在的安基林-1受体.

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