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Updated: Sep 12, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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以基因组学为基础的药物再利用策略确定了两种治疗点,用于预防与代谢功能障碍相关的肝病

Hannah M Seagle1, Alexis T Akerele2, Joseph A DeCorte3

  • 1Vanderbilt University Genetics Institute, Department of Medicine, Vanderbilt University, Nashville, TN, USA; Joseph Maxwell Cleland Atlanta VA Medical Center, Atlanta, GA, USA; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

American journal of human genetics
|August 8, 2025
PubMed
概括

药物再利用为治疗疾病提供了一种有效的策略. 这项研究确定了FADS1和S1PR2作为预防代谢功能障碍相关脂肪性肝病 (MASLD) 的有希望的目标,分别使用icosapent ethyl和fingolimod.

关键词:
马斯尔德 马斯尔德是什么意思门德尔的随机化这是NAFLD.药物重用是为了改变药物的用途.这就是fingolimod的意思.艾科萨乙烯 (icosapent ethyl) 的使用情况分子对接的分子对接.分子动力学模拟模型蛋白质 - 药物复合体是指蛋白质 - 药物复合体转录组广泛的关联研究研究.

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