FAPI PET/CT用于跟踪肌肉炎相关的间歇性肺病的疾病轨迹
Kastriot Kastrati1, Svitlana Pochepnia2, Oana C Kulterer3
1Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
标有-68纤维细胞激活蛋白抑制剂 (FAPI) 的PET/CT在预测异常性炎症性肌肉病 (IIM) 中间歇性肺病 (ILD) 进展方面显示出前景. 这种新型生物标志物可以改善IIM患者ILD的早期检测和个性化管理.
科学领域:
- 放射学和核医学 放射学和核医学
- 肺部病理学 肺部病理学
- 类风湿病学 类风湿病学
背景情况:
- 间歇性肺病 (ILD) 显著影响异常性炎症性肌肉病 (IIM) 的发病率和死亡率.
- 目前的诊断工具,如肺功能测试 (PFT) 和高分辨率计算机断层扫描 (HRCT),对ILD进展的预后准确性有限.
- 需要可靠的生物标志物来预测IIM中的ILD演变.
研究的目的:
- 评估基线Ga标记纤维细胞激活蛋白抑制剂 (FAPI) PET/CT在IIM患者两年内预测ILD进展的潜力.
- 评估肺部FAPI标记物吸收的预后价值,以识别患有ILD进展风险的患者.
主要方法:
- 一项前性观察性研究涉及19名IIM患者 (14名ILD患者) 接受了基线[68Ga]Ga-FAPI PET/CT.
- 使用PFT标准,INBUILD标准和包括INBUILD标准加上不良临床结果的复合终点来定义ILD进展.
- 使用全肺最大和平均目标与背景比率 (wlTBRmax和wlTBRmean) 来量化肺标记物吸收.
主要成果:
- 在两年内,很大一部分患者符合进展标准 (28.6%通过PFT,42.9%通过INBUILD,57.1%通过复合终点).
- 较高的基线 wlTBRmax和 wlTBRmean与ILD进展显著相关,根据INBUILD标准和复合终点 (p <0.05).
- 与单独PFT和HRCT相比,结合肺部wlTBRmax和wlTBRmean可以提高ILD进展的预测准确性.
结论:
- 68Ga]Ga-FAPI PET/CT可以作为一种非侵入性生物标志物,用于在IIM中早期预测ILD进展.
- 这种成像模式支持针对IIM相关ILD的个性化疾病管理策略.
- 由于小规模的单中心队列,研究结果是初步的,需要在更大的多中心研究中进行验证.
更多相关视频
07:38A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in Mice
Published on: April 13, 2018
04:44Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
相关概念视频
Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Radiological Investigation II: MRI and Ventilation Perfusion Scan
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
