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水平与败血症中短期死亡率之间的U形关系
Süleyman Alpar1, Ali Cankut Tatlıparmak2
1Emergency Physician, Faculty of Medicine, İstanbul Beykent University, Istanbul, Turkey.
The American journal of emergency medicine
|August 8, 2025
概括
败血症患者的异常血清水平 (失血症) 与30天死亡风险更高有关. 在急诊室 (ED) 进行早期的评估可以帮助对败血症的风险分层.
科学领域:
- 临界护理医学 临界护理医学
- 电解质干扰 电解质干扰
- 败血症病理生理学病理生理学
背景情况:
- 失水症是重症患者的常见并发症,特别是患有败血症的患者.
- 血清水平的异常对败血症的结果具有显著的预后影响.
研究的目的:
- 调查入院血清水平与败血症患者30天死亡率之间的独立关联.
- 在急诊室 (ED) 呈现时,评估血清度的全谱死亡风险.
主要方法:
- 对793名通过ED入院的成人败血症患者进行了回顾性队列研究.
- 缺血症定义为血清<135或>145mmol/L;主要结局是30天全因死亡率.
- 多变量逻辑回归和通用添加式建模 (GAM) 分析了与死亡率的关联,并调整了共变量.
主要成果:
- 整体30天死亡率为23.0%.
- 缺血症独立预测增加了30天死亡率 (aOR:4.06,p=0.002).
- 血清和死亡率之间观察到非线性关系,极端的低和高血显示出更高的风险.
结论:
- 在呈现时异常的血清水平与败血症的短期死亡率独立相关.
- 度测量对于早期临床评估和ED中败血症患者的风险分层有价值.
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