长期COVID患者的功能性连接性变化 有或没有认知障碍的患者
Manuel Leitner1, Daniela Pinter2, Stefan Ropele3
1Department of Neurology, Medical University of Graz, Graz, Austria; Department of Medical Psychology, Psychosomatics and Psychotherapy, Medical University of Graz, Graz, Austria.
长期Covid与认知问题有关. 脑部扫描显示,认知缺陷患者的默认模式网络和视觉腹腔流中的功能连接发生了变化,这表明有不适应性变化.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 长期Covid经常与影响记忆,注意力和执行功能的认知障碍有关.
- 在患有认知缺陷的长期Covid患者中,潜在的大脑结构和功能变化仍然不完全理解.
- 休息状态功能磁共振成像 (fMRI) 为调查大脑网络变化提供了有价值的工具.
研究的目的:
- 研究长期COVID患者与没有认知障碍之间的大脑结构和功能差异.
- 确定与长期Covid的认知缺陷相关的特定静止状态网络变化.
- 探索功能连接变化与认知表现之间的关系.
主要方法:
- 从39名长期COVID患者获得结构和功能静止状态MRI扫描.
- 根据认知障碍 (≥1个领域的缺陷) 和没有障碍,患者被分为两组.
- 分析的重点是静态网络 (网络内部和网络之间) 和灰色物质/亚皮层体积的差异.
主要成果:
- 认知障碍的长期Covid患者在默认模式网络 (DMN) 和特定的脑后区域之间表现出更高的功能连接 (FC).
- 在认知障碍患者中观察到视觉和腹腔流网络之间的连接性增加.
- 两组之间没有发现灰质或皮层下区域的显著体积差异.
结论:
- 功能连接的改变,特别是涉及DMN和视觉腹腔流,与长期Covid的认知缺陷有关.
- 这些发现表明,不适应的功能性大脑变化有助于COVID-19后的认知障碍.
- 神经成像可以帮助阐明长期Covid的认知功能障碍背后的机制.
更多相关视频
09:01A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
Published on: May 7, 2014
09:26Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
Published on: February 6, 2019
相关概念视频
Cognitive Development During Adulthood
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Classification of Illness
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
