Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
The Thyroid Gland01:23

The Thyroid Gland

4.3K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.3K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.2K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.2K
The Parathyroid Glands00:59

The Parathyroid Glands

2.5K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.5K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

4.8K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.8K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

2.4K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
2.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Best Practice Recommendations for the Assessment, Prevention and Treatment of Vitamin D Deficiency in Türkiye: A 2026 Update in a Setting with Limited Mandatory Food Fortification.

Nutrients·2026
Same author

Evaluation of macular microcirculation in prediabetic patients using OCT angiography.

Photodiagnosis and photodynamic therapy·2026
Same author

Telomere length in patients with non-functional adrenal incidentalomas.

Endocrine journal·2026
Same author

Assessing the impact of quality of life and complications on diabetes distress in adults with Type 2 Diabetes.

JPMA. The Journal of the Pakistan Medical Association·2026
Same author

Real-World Comparison of Short-Term Adverse Events, Treatment Persistence, and Efficacy of Semaglutide and Tirzepatide: A Nationwide Multicenter Study.

Obesity facts·2026
Same author

Workplace and Healthcare Stigma in Hereditary Angioedema: Links to Anxiety and Functional Impairment.

Healthcare (Basel, Switzerland)·2026

相关实验视频

Updated: Sep 12, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.8K

甲状腺疾病中的IgG4水平

Kutay Kirdok1, Nilufer Ozdemir2, Sedat Can Guney2

  • 1Department of Internal Medicine, Manisa Celal Bayar University, Manisa, Turkey.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
|August 8, 2025
PubMed
概括
此摘要是机器生成的。

免疫球蛋白G4 (IgG4) 水平升高可能会恶化格雷夫斯病和格雷夫斯眼病. 这项研究探讨了IgG4在各种甲状腺疾病中的作用,在Graves病患者中发现甲状腺功能测试值较高,IgG4增加.

更多相关视频

An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

11.7K
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

738

相关实验视频

Last Updated: Sep 12, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.8K
An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

11.7K
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

738

科学领域:

  • 内分泌学 在内分泌学.
  • 免疫学 免疫学 免疫学
  • 病理学 病理学 病理学

背景情况:

  • 与免疫球蛋白G4 (IgG4) 相关的疾病是IgG4抗体占据中心地位的炎症状况.
  • 这些IgG4相关的疾病可能会影响甲状腺,需要对IgG4在甲状腺病理中的作用进行调查.

研究的目的:

  • 为了确定各种甲状腺疾病群体IgG4水平的差异.
  • 分析IgG4水平与甲状腺功能测试,自身抗体和甲状腺体积之间的相关性.

主要方法:

  • 包括151名患有甲状腺疾病的患者 (格雷夫斯病,哈希莫托甲状腺炎,自身抗体阴性甲状腺结节) 和48名健康对照.
  • 根据IgG4水平和IgG4/IgG比率进行统计分析,对患者进行分类.
  • 在定义的患者群体中比较IgG4水平和IgG4/IgG比率.

主要成果:

  • 在四个主要的甲状腺疾病组中,没有发现IgG4或IgG4/IgG比率的统计学上显著差异.
  • 患有IgG4水平≥135 mg/dl和IgG4/IgG比率≥8%的格雷夫斯病患者表现出明显更高的自由T3,自由T4和赫特尔值.
  • 这些发现表明,升高的IgG4在格雷夫斯病及其相关的眼病中可能会加剧其作用.

结论:

  • 免疫球蛋白G4 (IgG4) 可能在甲状腺疾病的病理生理学中发挥重要作用.
  • 升高的IgG4水平似乎加剧了Graves病和Graves眼病的临床表现和进展.
  • 进一步的研究至关重要,以充分理解IgG4在管理和监测甲状腺疾病进展中的临床意义.