帕克蒂娜尼格雷森斯 (Parquetina nigrescens) 树叶提取物减轻了牛肉中阿弗拉托克素B1引起的压力,免疫和生长障碍
Olugbenga D Oloruntola1, Adeyeye S Adebowale2, Andrew B Falowo1
1Department of Animal Science. Adekunle Ajasin University, Akungba Akoko, Nigeria.
概括
帕基蒂娜尼格雷森斯 (Parquetina nigrescens) 叶片提取物 (PNLE) 有效地对抗 brojler 的阿弗拉托克辛B1 (AFB1) 毒性. 补充PNLE可以改善抗氧化剂状况,免疫反应和生长性能,为家禽生产提供了实际的解决方案.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 动物营养 动物营养
- 毒理学 毒理学 毒理学
背景情况:
- 禽类料中阿弗拉托克素B1 (AFB1) 污染存在重大风险,损害肉免疫力,诱导氧化应激,并对生长和尸体质量产生负面影响.
- 了解天然化合物对AFB1毒性的缓解作用对于改善家禽健康和生产率至关重要.
研究的目的:
- 为了评估Parquetina nigrescens叶提取物 (PNLE) 对肉AFB1诱导的免疫炎症,氧化和代谢障碍的保护效果.
- 确定PNLE的最佳剂量,以减轻AFB1毒性并提高肉的性能.
主要方法:
- 200只肉被分为四组:对照组,只有AFB1,AFB1+1g/LPNLE和AFB1+2g/LPNLE.
- 测量了关键的生理,免疫,氧化应激和性能参数,包括生长速度,尸体产量,细胞因子水平,免疫球蛋白度和抗氧化酶活性.
- 进行了相关性分析,以将免疫标记物和炎症性细胞因子与性能指标联系起来.
主要成果:
- 暴露于AFB1显著降低了生长速度,包裹百分比和抗氧化活性,同时增加了促炎性细胞因子和器官重量.
- PNLE补充剂,特别是2g/L,显著改善了AFB1诱导的负面影响,改善了抗氧化状态,免疫反应 (免疫球蛋白和T3升高) 和整体性能.
- 在生长率和免疫标志物 (IgM,IgA) 之间观察到显著的正相关性,以及与促炎性细胞因子 (IL-1β,IL-6) 的负相关性.
结论:
- 帕克蒂娜尼格雷森斯 (Parquetina nigrescens) 叶片提取物有效地减轻肉中AFB1诱导的毒性,支持免疫能力和减少炎症.
- 建议在饮用水中使用PNLE补充剂水平为2g/L,作为对抗家禽生产中 aflatotoxicosis的实际和有效策略.
- 这些发现强调了免疫状况和炎症控制对 brojiler生产率的重要性,以及天然提取物在料安全方面的潜力.
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