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来自鱼软骨的富含的糖氨基甘:特征和潜在的抗代谢综合征

Yanbin Gao¹, Jiaxi Lin², Dan Liu¹

¹Shaanxi Provincial Rehabilitation Hospital, Xian 710065, China.

International journal of biological macromolecules

|August 8, 2025

概括

一种新型的富含的丁硫酸盐 (CSSE) 通过改善抗氧化能力,葡萄糖水平和肠道健康,有效地对抗代谢综合征. 与无机相比,这种来自海洋的化合物显示出更高的疗效和安全性.

科学领域:

生物化学和分子生物学
营养药和功能性食品营养药和功能性食品
海洋生物技术海洋生物技术
代谢健康代谢健康

背景情况:

由高碳水化合物/高脂肪饮食引起的代谢综合征构成了全球重大健康挑战.
现有疗法通常在疗效和副作用方面存在局限性,需要新的治疗策略.
来自海洋的生物活性化合物为开发先进的营养药和治疗药物提供了潜力.

研究的目的:

开发和表征一种从石软骨中提取的富含的新型冠状素硫酸盐 (CSSE).
评估CSE对抗饮食诱导的代谢综合征的多目标治疗潜力.
研究CSSE作用的潜在机制,包括其对细胞通路和肠道微生物群的影响.

主要方法:

使用核磁共振 (NMR) 和MALDI-TOF质谱法对CSSE进行结构性表征.
在体外评估抗氧化能力和生物相容性与烯酸相比.
在高碳水化合物/高脂肪饮食养小鼠的体内疗效研究,分析代谢参数,信号通路 (mTORC1,PI3K-Akt),肠肝轴 (FGF21/FGF19) 和肠道微生物群组成.
便微生物群移植 (FMT) 用于验证微生物群依赖的影响.

主要成果:

CSSE表现出强大的抗氧化活性 (65-80%的DPPH清除) 和优越的生物相容性 (89.5%的细胞活力) 与化相比.
在HCHF养的小鼠中,CSSE显著减少了体重增加 (-35%),禁食葡萄糖 (-55%) 和甘油三 (-44%),表现优于无机.
CSSE调节了关键的代谢途径,包括mTORC1抑制,胰岛素信号恢复 (PI3K-Akt/IRS-1),以及增强的FGF21/FGF19信号.
CSSE积极改变了肠道微生物群,增加了短链脂肪酸 (SCFA) 产量 (58.1%),并改善了肠道屏障功能 (减少了FITC-dextran泄漏49%).

结论:

通过抗氧化剂,降脂和肠道调节作用,CSSE在改善饮食诱导的代谢综合征方面表现出显著的多目标疗效.
向性肝脏输送和有利的安全概况将CSSE定位为有前途的海洋有机治疗药物.
这项研究强调了一种可持续的方法,利用水产养殖副产品制成高价值的营养品,以促进新陈代谢健康,符合循环生物经济的原则.

关键词:

生物活性生物活性标志性描述标志性描述顺德罗因丁硫酸盐硫酸.鱼是一种鱼.

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