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Assaying Protein Kinase Activity with Radiolabeled ATP
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BCI通过向激酶结合域和破坏ERK2相互作用来抑制MKP3

Su-Jie Qiu1, Ya-Liang Zhang2, Wei-Bin Gong3

  • 1Institute of Molecular Enzymology, School of Life Sciences, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, P.R. China; MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, P.R. China.

The Journal of biological chemistry
|August 8, 2025
PubMed
概括

小分子抑制剂BCI选择性地与Mitogen激活蛋白激酶酸酶3 (MKP3) 的激酶结合域结合,破坏其与ERK2.2的相互作用. 这种新的全性机制为开发针对癌症等疾病的酸酶抑制剂提供了新的策略.

关键词:
这是一种BCI抑制剂.MAPK 酸酶 3 的作用.双重特异性的酸酶6细胞外信号受调节的激酶.通过基因激活的蛋白质激酶.

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