双相情绪障碍中非自杀性自我伤害中的炎症和冲动性路径:一项为期24周的纵向队列研究
Yinglin Han1, Xinxin Huang1, Yishan Du1
1Department of Psychiatry, Nanjing Medical University Affiliated Brain Hospital, No.264 Guangzhou Road, Nanjing 210029, China.
Journal of affective disorders
|August 8, 2025
概括
在双相情绪障碍 (BD) 中,非自杀性自我伤害 (NSSI) 与炎症和认知控制缺陷有关. 双通道模型表明,炎症和冲动性都会随着时间的推移导致NSSI的发展.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 非自杀性自我伤害 (NSSI) 是双相情感障碍 (BD) 的一个重要问题,增加了自杀风险.
- 连接炎症,认知控制和冲动性到BD中的NSSI的纵向机制仍然不太了解.
研究的目的:
- 在患有双相情感障碍的患者中,研究炎症标记,认知控制,冲动性和NSSI之间的纵向关系.
- 为了阐明这些因素在24周期间的时间动态.
主要方法:
- 一项为期24周的纵向研究,共400名参与者 (200名BD与NSSI,100名BD没有NSSI,100名对照).
- 评估炎症标志物 (IL-6,CRP),认知任务 (Go/No-Go,DSST),冲动性 (BIS-11) 和临床特征在基线,第12周和第24周.
- 采用线性混合模型,层次回归,结构方程建模 (SEM) 和时间变化的潜增长建模 (LGM).
主要成果:
- BD + NSSI组表现出持续升高的IL-6和CRP,随着时间的推移,IL-6的增加.
- SEM显示CRP通过受损的寒冷抑制控制 (Go/NoGo任务) 影响了NSSI的严重程度.
- 时间变化的LGM表明冷抑制介导的CRP和IL-6在后期对NSSI的影响,这表明对执行控制的渐进性炎症影响.
- 发现高冲动性可以减弱炎症-NSSI通路,这表明一种明显的冲动性驱动子类型.
结论:
- 这些发现支持双通道模型,用于双相情感障碍中的NSSI.
- 这个模型涉及与炎症相关的认知功能障碍和特征冲动性.
- 随着时间的推移,与CRP相关的急性和慢性IL-6介导的炎症通过认知和情感机制导致NSSI.
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