在病进展过程中,照射牙的物理和生化变化
Leonardo Moreira Teodosio1, Alexandra Mussolino de Queiroz2, Harley Francisco de Oliveira3
1Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, 14040-904, Ribeirão Preto, São Paulo, Brazil.
Journal of dentistry
|August 8, 2025
概括
放射治疗改变了牙,减少了矿物质密度,增加了根中的原蛋白对腐烂的抵抗力. 这会影响牙在照射牙中的进展,因此需要为接受放射治疗的患者提供量身定制的牙科护理.
科学领域:
- 牙科研究 牙科研究
- 生物材料科学是生物材料的科学.
- 在瘤学瘤学.
背景情况:
- 放射治疗可以导致口腔组织的显著变化.
- 了解这些变化对于在接受癌症治疗的患者中治疗牙至关重要.
研究的目的:
- 为了研究暴露于放射治疗的牙中牙损伤的物理和化学变化.
- 为了确定放射治疗对牙进展的影响.
主要方法:
- 一个采用人类大犬的体外模型,分为照射和对照组.
- 对矿物密度 (微计算机断层扫描),生物化学成分 (拉曼光谱),病变深度/孔隙度 (聚焦显微镜) 和原超结构 (组织学染色) 的牙分析.
主要成果:
- 被辐射的牙在冠状和根层中显示矿物质密度降低.
- 拉曼光谱检测表明,在照射的根脏中,原蛋白结构发生了变化 (托西丁减少,胺I增加).
- 被辐射的根牙对原降解更具抵抗力,尽管损伤深度和毛孔度没有显著差异.
结论:
- 放射治疗引起的牙变化会影响皮的进展,特别是矿物质密度和根系原敏感性.
- 研究结果支持基于证据的病管理策略,用于接受放射治疗的患者.
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