组织大脑范围的输入到离散的横隔膜投射群体
Jennifer Isaac1, Sonia Karkare1, Hymavathy Balasubramanian1
1Emory Neuroscience Graduate Program, Emory University, Atlanta, GA 30322.
概括
侧隔膜 (LS) 指导社会行为信息. 这项研究绘制了LS投影及其输入,揭示了不同的解剖组织和特定的连接模式,这对于理解LS在社会行为中的功能至关重要.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 解剖学的连接性 解剖学的连接性
背景情况:
- 侧隔膜 (LS) 对于社会行为至关重要,它将海马和皮质连接到皮下区域.
- 之前的研究集中在LS下丘脑输出上,使得非下丘脑预测及其输入的理解很差.
- 了解LS连接是解读它在各种社会行为中的作用的关键.
研究的目的:
- 将侧隔膜组织 (LS) 预测映射到雄性小鼠的六个关键社会行为大脑区域.
- 为了全面地映射大脑宽度输入到这些不同的LS投影群体.
- 阐明LS的功能异质性的解剖基础.
主要方法:
- 逆行追踪被用来识别LS投射到底侧杏仁体,结核的床核,核,周水管灰色,腹中下丘脑和腹膜区域.
- 单突触狂犬病追踪被用来映射大脑范围的输入到这些特定的LS投影群体.
- 在雄性小鼠身上进行了实验.
主要成果:
- 发现LS投射种群占据了LS内的离散解剖隔间.
- 对于每个LS投影群体来说,发现了独特的,取决于区域的大脑输入模式.
- 在LS投射种群中观察到皮质,海马和乳头层输入的差异,而下丘脑输入在很大程度上保持了.
结论:
- 侧面隔膜表现出高度的空间组织和输入特异性.
- 不同的LS投影群体会收到独特的信息流,特别是来自皮质,海马和胸膜区域.
- 这种解剖组织为LS如何选择性地处理信息以调节社会行为提供了一个电路级的框架.
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