与感染相关的静脉血栓塞栓症:系统性审查和元分析
Panagiotis Stathopoulos1, Stelios-Elion Bousi1, Marinos Zachiotis1
1Alfa Institute of Biomedical Sciences, Athens, Greece.
European journal of internal medicine
|August 8, 2025
概括
感染显著增加了静脉血栓栓塞 (VTE) 的风险. 这一元分析证实了感染和VTE之间的强烈,一致的联系,突出了当前对感染性疾病患者的风险评估中的潜在差距.
科学领域:
- 医学研究 医学研究
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 静脉血栓塞栓症 (VTE) 是疾病和死亡的重要原因.
- 在VTE和感染之间的联系是公认的,但没有完全量化.
研究的目的:
- 系统地审查和元分析感染和VTE之间的关联.
- 综合感染-VTE关联的发生率和强度.
主要方法:
- 21项研究的系统审查和元分析.
- 包括病例控制,病例交叉和回顾性队列设计.
- 排除了关于局部皮肤感染,产后,恶性瘤,高凝血,骨科,COVID-19,HIV和细胞巨乳病毒的研究.
主要成果:
- 在21项研究中,20项研究显示,感染的VTE发病率显著增加.
- 在研究设计中发现了强烈的关联:OR 3.35 (病例控制),OR 5.81 (病例交叉),OR 2.69 (队列).
- 协会在各种环境,时间间隔和感染地点中一致;与细菌感染有显著联系 (OR 2.81).
结论:
- 感染始终与更高的VTE风险有关.
- 在目前的VTE风险评估工具中,这种关联可能被低估了.
- 对传染病患者的预防性抗凝药的进一步研究是有必要的.
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