在儿童中困难的Clostridioides
Larry K Kociolek1, Thomas J Sandora2, Preeti Mehrotra3
1Department of Pediatrics, Northwestern University Feinberg School of Medicine; Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Avenue, Box 20, Chicago, IL 60611, USA.
Infectious disease clinics of North America
|August 8, 2025
概括
儿童Clostridioides difficile感染 (CDI) 发病率正在下降,与社区相关的病例更为常见. 建议使用万科米辛作为一线治疗,其他疗法对复发性CDI有效.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 在过去的二十年中,儿童中硬性杆菌感染 (CDI) 的发病率显著增加.
- 虽然整体儿科CDI发病率在过去五年中有所下降,但社区相关的CDI仍然是一个重大问题.
- 对于儿科CDI的社区获取来源尚未得到充分了解,这使诊断和预防工作复杂化.
研究的目的:
- 要总结当前儿童Clostridioides困难感染 (CDI) 的趋势.
- 突出在儿童群体中诊断CDI的挑战.
- 审查儿科CDI推和新兴的治疗策略.
主要方法:
- 关于儿科CDI发病率的最新流行病学数据的审查.
- 对诊断挑战的分析,包括婴儿和儿童的高殖民率.
- 评估当前和新兴的治疗指南和儿科CDI临床试验数据.
主要成果:
- 在过去五年中,儿童CDI发病率在之前显著增加后有所下降.
- 社区相关的CDI在儿童中比医疗机构相关的CDI更为普遍.
- 范科米辛被建议作为儿科CDI的第一线治疗.
- 菲达克索米辛和便微生物群移植证明了对儿科复发性CDI的安全性和有效性.
结论:
- 尽管近年来CDI的数量有所下降,但它仍然是一个重要的公共卫生问题,特别是社区相关的感染.
- 儿童中CDI的准确诊断因高殖民率而复杂化.
- 目前的证据支持万科米辛作为主要治疗方法,而菲达克索米辛和FMT是复发病例的可行选择.
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