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Updated: Sep 12, 2025

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
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Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

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矩阵刚性驱动阿尔代代谢的改变,诱导DNA损伤和转化

Matthew Jones1,2, Hannah Percival2, Alis Hales1,2

  • 1Manchester Cell Matrix Centre, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

Scientific reports
|August 8, 2025
PubMed
概括

乳腺组织中细胞外矩阵 (ECM) 刚度的增加会改变乳腺上皮细胞 (MEC) 代谢,导致DNA损伤和癌症发病. 这项研究揭示了ECM刚性如何驱动乳腺癌中的基因组不稳定性.

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