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瞳孔尺寸调节驱动小鼠视网膜活动,并塑造人类的感知

Tjasa Lapanja^1,2, Pietro Micheli^1,3, Andrés González-Guerra¹

¹Epigenetics and Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Monterotondo, 00015, Italy.

Nature communications

|August 8, 2025

概括

瞳孔光反射 (PLR) 或瞳孔收缩,积极驱动视网膜质细胞 (RGC) 活动,并有意识地感知到. 这表明,瞳孔在编码光感知方面发挥着直接作用.

科学领域:

神经科学是一个神经科学.
视觉科学科学视觉科学
眼科医生眼科眼科

背景情况:

学生在视觉中的作用主要被认为是被动的,调节光线的进入,以防止视网膜过度刺激.
视网膜中的神经元活动通常被认为独立于瞳孔动态.

研究的目的:

调查瞳孔光反射 (PLR) 是否积极影响视网膜质细胞 (RGC) 活动.
为了确定瞳孔驱动的神经反应是否被转发到视觉皮质并被意识地感知.

主要方法:

在小鼠RGCs的体内电生理学记录.
小鼠视觉皮层中的电生理学.
在人类志愿者身上进行心理实验.

主要成果:

瞳孔收缩 (PLR) 在小鼠所有研究的RGC类型中诱导了显著的神经活动.
这种由瞳孔驱动的活动被传递到视觉皮层.
同意的PLR使双眼对单眼亮度变化的双眼反应成为可能.
人类参与者报告了与PLR诱导的反应相关的感知变暗.

结论:

瞳孔光反射不仅仅是一个被动的光调节器,而是RGC活动的积极驱动器.
瞳孔动态直接促进视觉处理,并被意识地感知.
瞳孔在编码感知到的环境亮度方面发挥着积极的作用.

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