肺结核学生的耐药性:一个基于查的研究在河南,中国
Jiying Xu1,2, Yanqiu Zhang3, Guojie Wang4
1Institute of Tuberculosis Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan, China. xujiyingx@163.com.
BMC infectious diseases
|August 8, 2025
概括
在中国河南的学生中,耐药结核病 (DR-TB) 发生率从2015年至2021年显著下降. 以前接受过治疗的学生和男性患DR-TB的风险更高.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 在学校环境中构成爆发的重大风险.
- 学校的耐药结核病 (DR-TB) 疫情令人担忧,但学生群体中DR-TB概况的数据仍然有限.
- 本研究通过检查中国河南省的学生中DR-TB流行率和相关因素来解决这一差距.
研究的目的:
- 确定河南省学生中耐药结核病 (DR-TB) 的流行率.
- 在这个学生群体中确定与DR-TB相关的因素.
主要方法:
- 对3527例肺结核学生病例的回顾性审查,其中培养确认了Mycobacterium结核病分离物 (2015-2021年).
- 对抗药性结核病发病率的分析,包括任何抗药性结核病,利法抗药性 (RR-TB) 和多药性抗药性 (MDR-TB).
- 使用奇平方/费舍尔精确测试和后勤回归来识别相关因素的统计分析.
主要成果:
- 在学生中,DR-TB,RR-TB和MDR-TB的总体发病率分别为10.46%,7.91%和6.10%,显示2015年至2021年的下降趋势 (p < 0.001).
- 与新病例相比,以前接受治疗的病例患DR-TB,RR-TB和MDR-TB的几率明显更高.
- 河南西部学校的学生,男性,以及那些在各县之间迁移的人,患有DR-TB,RR-TB和MDR-TB的几率增加.
结论:
- 在河南省2015年至2021年期间,在河南省的学生中,DR-TB患病率显著下降.
- 以前接受过治疗的个人和河南西部学校的学生患DR-TB,RR-TB和MDR-TB的风险更高.
- 需要进一步的研究来调查在学生迁移到各县之间增加的MDR-TB的风险.
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