睡眠,体力活动,久坐行为和白内障风险:英国生物银行的一项横截面和前性研究
Yu Peng1, Yuzhou Zhang1, Ka Wai Kam1,2
1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
BMC medicine
|August 8, 2025
概括
睡眠不足,体力活动低 (PA) 和久坐不动 (SB) 会增加白内障的风险. 改变这些日常习惯可以显著降低患白内障的几率.
科学领域:
- 眼科医生 眼科 眼科
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 白内障是全球视力障碍的主要原因之一.
- 关于睡眠,体力活动 (PA) 和久坐行为 (SB) 等日常行为与白内障风险之间的联系仍在争论中.
- 这项研究调查了睡眠,PA和SB对白内障风险的独立和联合影响.
研究的目的:
- 分析睡眠,PA和SB与白内障风险的独立关联.
- 评估这些行为对白内障发展的综合影响.
- 为减轻白内障风险提供生活方式修改的证据.
主要方法:
- 利用英国生物库数据从440,645名参与者进行横截面分析和426,540人进行纵向分析.
- 透过医院记录和自我报告发现的白内障病例.
- 逻辑回归和考克斯比例危险模型评估了睡眠,PA,SB和白内障风险之间的关联.
主要成果:
- 睡眠不足,低PA和高SB在横截面和纵向分析中独立地与白内障风险增加有关.
- 睡眠不足,低PA和高SB的组合显示白内障风险显著增加 (OR1.73,HR1.37).
- 用PA或睡眠代替1小时的SB,白内障风险分别降低1.7%和2.7%.
结论:
- 睡眠不足,低血压和高血压是白内障的重要独立和联合危险因素.
- 生活方式的修改,包括改善睡眠,增加PA,减少SB,可以有效降低白内障风险.
- 这些发现支持公共卫生倡议,促进健康的日常行为,以预防视力障碍.
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